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A randomized, controlled, crossover study in patients with mild and moderate asthma undergoing treatment with traditional Chinese acupuncture
Pai, Hong Jin; Azevedo, Raymundo Soares; Braga, Alfésio Luís Ferreira; Martins, Lourdes Conceição; Saraiva-Romanholo, Beatriz M.; Martins, Milton de Arruda; Lin, Chin An.
Afiliação
  • Pai, Hong Jin; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Azevedo, Raymundo Soares; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Braga, Alfésio Luís Ferreira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Martins, Lourdes Conceição; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Saraiva-Romanholo, Beatriz M.; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Martins, Milton de Arruda; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Lin, Chin An; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Clinics ; Clinics;70(10): 663-669, Oct. 2015. tab, graf
Article em En | LILACS | ID: lil-762962
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

This study sought to verify the effects of acupuncture as an adjuvant treatment for the control of asthma.

METHODS:

This was a randomized, controlled, crossover trial conducted at the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. A total of 74 patients with mild/moderate, persistent asthma were randomized into two therapeutic groups Group A - 31 patients underwent 10 real weekly acupuncture sessions, followed by a 3-week washout period and 10 sham weekly acupuncture sessions; and Group B - 43 patients underwent 10 sham weekly acupuncture sessions, followed by a 3-week washout period and 10 real weekly acupuncture sessions. Patients used short- and long-acting β-2 agonists and inhaled corticosteroids when necessary. Prior to treatment and after each period of 10 treatment sessions, the patients were evaluated for spirometry, induced sputum cell count, exhaled nitric oxide (NO) and with the Short Form 36 (SF-36) and Questionnaire on Quality of Life-Asthma (QQLA) questionnaires. Daily peak flow and symptom diaries were registered. The level of significance adopted was 5% (α=0.05).

RESULTS:

In Group B, after real acupuncture, there was a decrease in eosinophils (p=0.035) and neutrophils (p=0.047), an increase in macrophages (p=0.001) and an improvement in peak flow (p=0.01). After sham acupuncture treatment, patients experienced less coughing (p=0.037), wheezing (p=0.013) and dyspnea (p=0.014); similarly, after real acupuncture, patients reported less coughing (p=0.040), wheezing (p=0.012), dyspnea (p<0.001) and nocturnal awakening episodes (p=0.009). In Group A, there was less use of rescue medication (p=0.043). After the sham procedure, patients in Group A experienced less coughing (p=0.007), wheezing (p=0.037), dyspnea (p<0.001) and use of rescue medication (p<0.001) and after real acupuncture, these patients showed improvements in functional capacity (p=0.004), physical aspects (p=0.002), general health status (p<0.001) and vitality (p=0.019). Sham acupuncture also led to significant differences in symptoms, but these were not different from those seen with real acupuncture. Spirometry and exhaled NO levels did not show a difference between sham and real acupuncture treatment. In addition, no significant difference was demonstrated between treatments regarding the quality of life evaluation.

CONCLUSION:

Real and sham acupuncture have different effects and outcomes on asthma control. The crossover approach was not effective in this study because both interventions led to improvement of asthma symptoms, quality of life and inflammatory cell counts. Thus, sham acupuncture cannot serve as a placebo in trials with acupuncture as the main intervention for asthma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Asma / Terapia por Acupuntura / Medicina Tradicional Chinesa Tipo de estudo: Clinical_trials / Diagnostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Asma / Terapia por Acupuntura / Medicina Tradicional Chinesa Tipo de estudo: Clinical_trials / Diagnostic_studies Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil