[Endometrial study made during the continuous administration of microdoses of 30 micrograms of d-norgestrel]. / Estudio endometrial en la administraction continua de microdosis de 30 microgramos de d-Norgestrel.

PIP: 171 endometrium biopsies taken from 61 patients before and during treatment with daily doses of 30 mcg of d-norgestrel were studied. It was found that continuous treatment with this drug produces a number of changes in the endometrial mucus membrane, although they are less marked than those found during treatment with oral contraceptives of the combination type. The progestational effect appeared to take place earlier, and secretion began earlier, as shown by the appearance of subnuclear vacuoles. An atrophied endometrium was found in only 1 case, but this may be due to the fact that biopsies were not taken from patients showing amenorrhea. Considerable edema was frequently found in biopsies taken at all stages in the cycle. Despite the earlier appearance of the progestational effect, the development of the endometrium appeared to be less complete than in the case of normal patients without treatment. These changes may be related to the contraceptive action of d-norgestrel.^ieng