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An experimental model for the transplantation of fetal central nervous system cells to the injured spinal cord in rats.
de Barros Filho, Tarcísio Eloy Pessoa; de Oliveira, Reginaldo Perilo; Tsanaclis, Ana Maria; de Barros, Erika Meirelles Kalil Pessoa; Cristante, Alexandre Fogaça; Palma, Ricardo Moreira; dos Santos, Cristian Vilela; Marcon, Raphael Martus.
Afiliação
  • de Barros Filho TE; Department of Orthopaedics and Traumatology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
Rev Hosp Clin Fac Med Sao Paulo ; 57(6): 257-64, 2002.
Article em En | MEDLINE | ID: mdl-12612757
INTRODUCTION: Traumatic spinal cord injury is one of the most disabling conditions occurring in man and thus stimulates a strong interest in its histopathological, biochemical, and functional changes, primarily as we search for preventive and therapeutic methods. PURPOSE: To develop an experimental model for transplantation of cells from the fetal rat central nervous system to the site of an injured spinal cord of an adult rat in which the transplanted cells survive and become integrated. This experimental model will facilitate investigations of factors that promote regeneration and functional recovery after spinal cord trauma. MATERIAL AND METHODS: Fifteen adult Wistar rats underwent laminectomy, and an spinal cord lesion was made with microdissection. Fetal spinal cord tissue was then transplanted to the site of the injury. The rats were monitored over a 48-hour period, and then their vertebral column was completely removed for histological analysis. RESULTS: In 60% of transplanted rats, the fetal tissue at the injured site remained viable in the site of the lesion.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Traumatismos da Medula Espinal / Transplante de Tecido Fetal / Transplante de Células-Tronco Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Rev Hosp Clin Fac Med Sao Paulo Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Traumatismos da Medula Espinal / Transplante de Tecido Fetal / Transplante de Células-Tronco Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Rev Hosp Clin Fac Med Sao Paulo Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil