Stress-induced release of HSC70 from human tumors.
Cell Immunol
; 222(2): 97-104, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12826079
In this study, we demonstrate that the pro-inflammatory cytokine interferon-gamma (IFN-gamma) induces the active release of the constitutive form of the 70-kDa heat shock protein (HSC70) from K562 erythroleukemic cells. Treatment of K562 cells with IFN-gamma induced the upregulation of the inducible form of the 70-kDa heat shock protein (HSP70), but not the constitutive form of HSC70 within the cytosol, in a proteasome-dependent manner. In addition, IFN-gamma induced the downregulation of surface-bound HSC70, but did not significantly alter surface-bound HSP70 expression. These findings indicate that HSC70 can be actively released from tumor cells and is indicative of a previously unknown mechanism by which immune modulators stimulate the release of intracellular HSC70. This mechanism may account for the potent chaperokine activity of heat shock proteins recently observed during heat shock protein-based immunotherapy against a variety of cancers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon gama
/
Proteínas de Choque Térmico HSP70
/
Células K562
/
Temperatura Alta
Limite:
Humans
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Holanda