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HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.
Adams, L D; Tomasselli, A G; Robbins, P; Moss, B; Heinrikson, R L.
Afiliação
  • Adams LD; Biochemistry Unit, Upjohn Laboratories, Kalamazoo, MI 49001.
AIDS Res Hum Retroviruses ; 8(2): 291-5, 1992 Feb.
Article em En | MEDLINE | ID: mdl-1540415
Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protease de HIV / Actinas / HIV-1 Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 1992 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protease de HIV / Actinas / HIV-1 Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 1992 Tipo de documento: Article País de publicação: Estados Unidos