HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.
AIDS Res Hum Retroviruses
; 8(2): 291-5, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1540415
Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protease de HIV
/
Actinas
/
HIV-1
Limite:
Humans
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
Estados Unidos