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Serum lead, cadmium, and zinc levels in newborns with neural tube defects from a polluted zone in Mexico.
Carrillo-Ponce, María de Lourdes; Martínez-Ordaz, Verónica Araceli; Velasco-Rodríguez, Víctor Manuel; Hernández-García, Andrés; Hernández-Serrano, María Concepción; Sanmiguel, Francisca.
Afiliação
  • Carrillo-Ponce Mde L; Centro de Investigación Biomédica de la Universidad Autónoma de Coahuila, Biomedical Research Center at the Autonomous University of Coahuila, Mexico.
Reprod Toxicol ; 19(2): 149-54, 2004 Dec.
Article em En | MEDLINE | ID: mdl-15501379
Serum lead, cadmium and zinc levels from 31 newborns with neural tube defects (NTD), and 54 healthy controls living in a polluted area in Mexico were estimated using atomic absorption spectrophotometry (AAS). NTD family history was found to be of greater importance in the case group (OR 6.95, 95% CI 1.51-36.3, p=0.002). In 25% of the children, serum lead concentrations were above the admissible maximum level (AML) of 10 microg/dL within 24 h of extra-uterine life. Cadmium concentrations were below the AML. Zinc deficiency was found in nine (29%) of the cases and four (9.3%) of the controls (p=0.04). The logistic regression multivariate analysis showed no correlation between NTD and high levels of any of these metals; however, a positive correlation was found to zinc deficiency (OR 5.0, 95% CI 1.07-23.00, p=0.04). These results focus attention to the surrounding nutritional and maternal health factors of major importance in disease etiology.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Cádmio / Poluição Ambiental / Chumbo / Defeitos do Tubo Neural Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male / Newborn País/Região como assunto: Mexico Idioma: En Revista: Reprod Toxicol Assunto da revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Cádmio / Poluição Ambiental / Chumbo / Defeitos do Tubo Neural Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male / Newborn País/Região como assunto: Mexico Idioma: En Revista: Reprod Toxicol Assunto da revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos