Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.
Neurochem Res
; 29(10): 1793-800, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15532533
ABSTRACT
We investigated whether intrastriatal (i.s.) administration of 5-aminolevulinic acid (ALA) induces oxidative damage and whether behavioral alterations induced by i.s. administration of ALA could be affected by antioxidants. Unilateral injection of ALA (6 micromol/striatum) increased (approximately 30%) thiobarbituric acid-reactive substances (TBARS), but did not affect striatal content of total thiol groups. ALA-induced body asymmetry was not prevented by pretreatment with ascorbic acid (100 mg/kg, s.c.), dimethyl sulfoxide (DMSO, 0.5 microl/striatum, i.s.) or ebselen (10 nmol/striatum, i.s.). ALA-induced convulsions were not prevented by ascorbic acid, but were partially prevented by DMSO and completely prevented by ebselen. Ebselen completely prevented the increase of striatal TBARS induced by ALA. Results obtained suggest the involvement of reactive species in ALA-induced convulsions and may be of value in understanding the physiopathology of neurological dysfunctions associated to ALA overload.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Azóis
/
Dimetil Sulfóxido
/
Compostos Organosselênicos
/
Ácido Aminolevulínico
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil