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[Feasibility of muscle-derived cell autotransplantation as a treatment for post-prostatectomy urinary incontinence].
Yao, Qi-sheng; Ye, Zhang-qun; Chen, Cong-bo; Wang, Xiao-kang; Wang, Wei-min; Chen, Li-xin.
Afiliação
  • Yao QS; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. hbsyyqsdr@163.com
Zhonghua Nan Ke Xue ; 11(4): 272-4, 277, 2005 Apr.
Article em Zh | MEDLINE | ID: mdl-15921257
OBJECTIVE: To explore the feasibility of muscle-derived cell autotransplantation in the treatment of post-prostatectomy urinary incontinence. METHODS: Skeletal muscle-derived cells (MDC) were isolated and purified by replate technique from 6 female SD rats, and then transduced with adenovirus carrying Lac-Z gene. About 5 x 10(6) of the transduced cells were injected autologously into the bladder neck of the animals. Tissues were harvested after 5 and 15 days for histological examination and X-gal staining. RESULTS: At 5 and 15 days after the autologous MDC transplantation, histological examination revealed no apparent sign of inflammation and inflammatory cell invasion, and X-gal staining showed a large number of cells dyed blue, indicating the survival of the autologous cells. CONCLUSION: Autotransplanted MDCs can survive permanently. Autologous muscle stem cell injection can be an effective treatment for post-prostatectomy urinary incontinence.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Prostatectomia / Incontinência Urinária / Transplante de Células / Músculo Esquelético Tipo de estudo: Etiology_studies Limite: Animals Idioma: Zh Revista: Zhonghua Nan Ke Xue Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: China País de publicação: China
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Prostatectomia / Incontinência Urinária / Transplante de Células / Músculo Esquelético Tipo de estudo: Etiology_studies Limite: Animals Idioma: Zh Revista: Zhonghua Nan Ke Xue Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: China País de publicação: China