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The IL-1 gene family and bone involvement in celiac disease.
Moreno, M L; Crusius, J B A; Cherñavsky, A; Sugai, E; Sambuelli, A; Vazquez, H; Mauriño, E; Peña, A S; Bai, J C.
Afiliação
  • Moreno ML; Department of Medicine, C. Bonorino Udaondo Gastroenterology Hospital, Buenos Aires, Argentina.
Immunogenetics ; 57(8): 618-20, 2005 Sep.
Article em En | MEDLINE | ID: mdl-16133447
Celiac disease (CD) is associated with decreased bone mineral mass. Its pathogenesis is multifactorial since both systemic and local mechanisms may play a role. Our objective was to determine whether single-nucleotide polymorphisms in genes encoding members of the interleukin-1 family are associated with bone damage measured by densitometry in a series of 71 adult CD patients assessed at diagnosis. When compared with non-carrier CD patients, carriers of allele T of the interleukin-1beta gene (IL1B-511T) had a significantly lower bone mass at the total skeleton level (p = 0.0484) and a greater prevalence of osteopenia/osteoporosis (p = 0.0102). To our knowledge, this is the first evidence on the association between a genetic predisposition and low bone mass in CD patients. This finding supports the postulated inflammation-associated bone loss pathogenesis as one of the causes of bone weakness in CD.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Doença Celíaca / Interleucina-1 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Immunogenetics Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Doença Celíaca / Interleucina-1 / Polimorfismo de Nucleotídeo Único Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Immunogenetics Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos