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Influence of orange juice in the levels and in the genotoxicity of iron and copper.
Franke, Silvia Isabel Rech; Prá, Daniel; Giulian, Raquel; Dias, Johnny Ferraz; Yoneama, Maria Lúcia; da Silva, Juliana; Erdtmann, Bernardo; Henriques, João Antonio Pêgas.
Afiliação
  • Franke SI; Curso de Nutrição, Departamento de Educação Física e Saúde, Universidade de Santa Cruz do Sul, UNISC, RS, Brazil.
Food Chem Toxicol ; 44(3): 425-35, 2006 Mar.
Article em En | MEDLINE | ID: mdl-16263202
World consumption of natural juices is increasing as a consequence of the human search for a healthier life. The juice production industry, especially for orange juice, is expanding in several countries and particularly in Brazil. Despite scientific data reporting beneficial properties derived from juice consumption, some components of juices have been identified as mutagenic or carcinogenic. Carcinogenic or genotoxic effects may be mediated by the interaction of juice components with transition metals or by sub-products of juice auto-oxidation. In this study, the mutagenic potential of orange juice and two metallic agents used in dietary supplementation, FeSO(4) and CuSO(4), were investigated using the comet assay in mouse blood cells (in vivo). Both metal compounds were genotoxic for eukaryotic cells after 24h treatment at the doses used. Significant damage repair was observed after 48h of treatment with the same compounds. Orange juice had a modulating effect on the action of metallic sulfates. In the case of iron treatment, the presence of the orange juice had a preventive, but not restorative, effect. On the other hand, in the case of copper treatment, the effects were both preventive and restorative. PIXE (particle induced X-ray emission) analysis indicated a positive correlation between DNA damage and the hepatic levels of iron and a negative correlation between whole blood copper and DNA damage. A negative correlation between hepatic iron and whole blood copper content was also seen in the treatment with both ferrous and cupric sulfates.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bebidas / Dano ao DNA / Compostos Ferrosos / Sulfato de Cobre / Citrus sinensis / Reparo do DNA Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bebidas / Dano ao DNA / Compostos Ferrosos / Sulfato de Cobre / Citrus sinensis / Reparo do DNA Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido