Plasma membrane oxidoreductases: effects on erythrocyte metabolism and redox homeostasis.
Antioxid Redox Signal
; 8(7-8): 1241-7, 2006.
Article
em En
| MEDLINE
| ID: mdl-16910771
Plasma membrane oxidoreductases (PMORs) have been found in the membranes of all cells. These systems have been studied extensively in the human erythrocyte, so much is known about their activity and effect on erythrocyte cellular functioning. PMORs have been shown to be involved in a number of events associated with cell growth and function in other cell lines, but perhaps their most important role, especially in the nucleus- free mature erythrocyte, is as a redox sensor. The PMOR reduces extracellular oxidants by using the reducing power of intracellular antioxidants, making the cell metabolism respond to changes in the local redox environment. Thus, the activity of the PMOR is closely linked to the metabolic status of the erythrocyte. The main intracellular reductant for this system is ascorbic acid; however, the cell must also have the ability to supply NADH for full activity. Nuclear magnetic resonance studies on the effects of extracellular oxidants on intracellular metabolism have increased our knowledge of the intimate link between PMOR activity and metabolism, and these studies are reviewed here in detail.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Membrana Eritrocítica
/
Eritrócitos
/
Homeostase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Antioxid Redox Signal
Assunto da revista:
METABOLISMO
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Austrália
País de publicação:
Estados Unidos