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Plasma membrane oxidoreductases: effects on erythrocyte metabolism and redox homeostasis.
Kennett, Eleanor C; Kuchel, Philip W.
Afiliação
  • Kennett EC; School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia.
Antioxid Redox Signal ; 8(7-8): 1241-7, 2006.
Article em En | MEDLINE | ID: mdl-16910771
Plasma membrane oxidoreductases (PMORs) have been found in the membranes of all cells. These systems have been studied extensively in the human erythrocyte, so much is known about their activity and effect on erythrocyte cellular functioning. PMORs have been shown to be involved in a number of events associated with cell growth and function in other cell lines, but perhaps their most important role, especially in the nucleus- free mature erythrocyte, is as a redox sensor. The PMOR reduces extracellular oxidants by using the reducing power of intracellular antioxidants, making the cell metabolism respond to changes in the local redox environment. Thus, the activity of the PMOR is closely linked to the metabolic status of the erythrocyte. The main intracellular reductant for this system is ascorbic acid; however, the cell must also have the ability to supply NADH for full activity. Nuclear magnetic resonance studies on the effects of extracellular oxidants on intracellular metabolism have increased our knowledge of the intimate link between PMOR activity and metabolism, and these studies are reviewed here in detail.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Membrana Eritrocítica / Eritrócitos / Homeostase Limite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Assunto da revista: METABOLISMO Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Membrana Eritrocítica / Eritrócitos / Homeostase Limite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Assunto da revista: METABOLISMO Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos