[Diagnostic value of positron emission tomography/computed tomography with fluorine-18 fluordeoxyglucose in patients with differentiated thyroid gland carcinoma, high thyroglobulin serum levels and negative iodine whole body scan]. / Valor diagnóstico da tomografia por emissão de pósitrons/tomografia computadorizada (PET-CT) com flúor-18 fluordeoxiglicose (FDG-18F) em pacientes com carcinoma diferenciado da tireóide, níveis séricos de tireoglobulina elevados e pesquisa de corpo inteiro com iodo negativa.
Arq Bras Endocrinol Metabol
; 51(4): 581-6, 2007 Jun.
Article
em Pt
| MEDLINE
| ID: mdl-17684619
PURPOSE: To evaluate the role of PET-CT with FDG-18F in the detection of recurrence and/or metastasis of differentiated thyroid carcinoma (DTC) in patients with elevated levels of thyroglobulin (TG) and negative whole body scan (WBS). PATIENTS AND METHOD: PET-CT findings of 25 patients were compared to histopathology evaluation and conventional imaging (CI). RESULTS: PET-CT scan was positive in 16 patients finding 14 true-positive and 2 false-positive cases (positive predictive value 87.5%). Nine patients had negative PET-CT; two had decrease of TG to undetectable levels. One patient had residual disease detected by post-therapeutic WBS. Six patients had no evidence of tumor during follow-up (mean time 16 months). PET-CT was concordant with CI in 52%, partially concordant in 12% and discordant in 36% (6 false-negatives and 3 false-positive of CI). We observed a tendency of increasing proportion of positive PET-CT with increasing TG. CONCLUSION: PET-CT scan with FDG-18F is useful in the detection of recurrence and/or metastases of DTC with high TG levels but negative WBS. It presents elevated positive predictive value and is superior to CI being more effective as higher the serum TG levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tireoglobulina
/
Neoplasias da Glândula Tireoide
/
Tomografia Computadorizada por Raios X
/
Carcinoma Medular
/
Compostos Radiofarmacêuticos
/
Fluordesoxiglucose F18
/
Tomografia por Emissão de Pósitrons
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
Brasil