Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery.
Bioorg Med Chem
; 15(22): 7012-20, 2007 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-17851079
ABSTRACT
A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharides (including glycosyl azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, S- and C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperacilina
/
Glicolipídeos
/
Sistemas de Liberação de Medicamentos
/
Aminoácidos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido