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Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD.
Marc, M M; Korosec, P; Kern, I; Sok, M; Ihan, A; Kosnik, M.
Afiliação
  • Marc MM; University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia. mateja.marc@klinika-golnik.si
Scand J Immunol ; 66(6): 694-702, 2007 Dec.
Article em En | MEDLINE | ID: mdl-17949407
Cytotoxic CD8+ T cells have been suggested to be key players in the pathogenesis of chronic obstructive pulmonary disease (COPD). We wanted to investigate the phenotype of lung tissue T lymphocytes (LTL) and tumour-infiltrating T lymphocytes (TIL) in smokers with peripheral non-small cell lung carcinoma (NSCLC) with moderate/severe versus mild COPD. Lung tissue and tumour samples were obtained from patients with moderate/severe stage of COPD (n = 10) and from patients with mild stage of COPD (n = 7) at lung resection for a solitary peripheral NSCLC, processed and analysed by flow cytometry. The flow-cytometric results showed that lung tissue T cells, regardless of the severity of COPD, were mostly of the activated phenotype, expressed the CXCR3 chemokine receptor characteristic of type 1 T cells, and did neither significantly differ in the expression of activation markers (CD69, CD25 and HLA-DR), differentiation markers (CD27 and CD28) and chemokine receptors (CXCR3 and CCR4) between the selected groups, nor showed any significant correlation with lung function measured as forced expiratory volume in 1 s (FEV1) or TLCO. Compared with LTL, a significantly greater proportion of TIL expressed the activation markers CD69 and CD25, but a lower proportion showed a fully differentiated CD27- 28- phenotype. We conclude that lung LTL patterns are similar in NSCLC patients with moderate/severe or mild stages of COPD, and are not significantly related to lung function. LTL and TIL possess different phenotype characteristics. The majority of tumour tissue T cells are activated, but it seems that their process of differentiation is incomplete.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Linfócitos do Interstício Tumoral / Carcinoma Pulmonar de Células não Pequenas / Doença Pulmonar Obstrutiva Crônica / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: Scand J Immunol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Eslovênia País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Linfócitos do Interstício Tumoral / Carcinoma Pulmonar de Células não Pequenas / Doença Pulmonar Obstrutiva Crônica / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male Idioma: En Revista: Scand J Immunol Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Eslovênia País de publicação: Reino Unido