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[Prognostic value of cyclin E and its relation to blood vessel invasion in rectal cancer].
Zhou, Yong-Jian; Wan, Feng-Ling; Yao, Li-Hua; Feng, Li-Ya.
Afiliação
  • Zhou YJ; Department of Colorectal Surgery, Peking University School of Oncology, Beijing Institute of Cancer Research, Beijing Cancer Hospital, Beijing 100036, China. zyjbju@sina.com
Zhonghua Wei Chang Wai Ke Za Zhi ; 11(2): 167-71, 2008 Mar.
Article em Zh | MEDLINE | ID: mdl-18344087
OBJECTIVE: To investigate the expression of cyclin E in rectal carcinoma and its prognostic significance. METHODS: Cyclin E expression was examined by Western blotting in tumor tissue samples from 130 potentially resected rectal cancer patients with pathological stages I- III. Blood vessel invasion (BVI) was detected by immunohistochemistry. Multivariate analysis using the COX proportional hazards models was applied to evaluate the independent prognostic tumor markers of rectal cancer. RESULTS: The high expression rate of cyclin E in rectal carcinoma tissue was 23.1%(30/130). Except for a positive correlation with BVI and the gross configuration of tumor, the expression of cyclin E showed no significant relation to other clinicopathological factors. The 5-year disease-specific survival rate of cyclin E high expression group was 29.2%, which was significantly lower as compared to that of cyclin low expression group 70.5% (P<0.05). Multivariate analysis revealed that histology and cyclin E expression were independent prognostic indicators for rectal cancer patients at stages I- III. Compared to those with low expression levels, patients with high cyclin E levels had the hazard ratio (95%CI) for death from rectal cancer for 3.544 (1.528-8.215). In stage I- II, multivariate analysis showed that stronger predictive values of cyclin E expression even were detected. Patients with low cyclin E expression and negative BVI had a significantly better prognosis than those with high cyclin E expression and positive BVI. CONCLUSIONS: The expression of cyclin E is independent prognostic factor in rectal carcinoma at stages I- III. Detecting the expression of cyclin E and/or combined with BVI may help to predict clinical outcome and design further individualized intensive adjuvant treatment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Ciclina E / Neovascularização Patológica Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: Zh Revista: Zhonghua Wei Chang Wai Ke Za Zhi Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: China País de publicação: China
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Ciclina E / Neovascularização Patológica Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: Zh Revista: Zhonghua Wei Chang Wai Ke Za Zhi Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: China País de publicação: China