A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.
J Org Chem
; 73(17): 6928-31, 2008 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-18690744
A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Tiofenos
/
Éteres
/
Mexiletina
/
Antiarrítmicos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Porto Rico
País de publicação:
Estados Unidos