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Activation of serotonin 5-HT1-receptors decreased gripping-induced immobility episodes in taiep rats.
Ita, Martha L; Cortés, Ma del Carmen; Valencia, Jaime; Eguibar, Jose R.
Afiliação
  • Ita ML; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Mexico.
Neurosci Lett ; 449(2): 147-50, 2009 Jan 09.
Article em En | MEDLINE | ID: mdl-18996171
The taiep rat is a myelin mutant that shows a disorganized sleep-wake cycle and immobility episodes (IEs) when the animals are gripped at the base of the tail. During IEs electroencephalographic recordings show a rapid eye movement (REM) sleep-like pattern. These alterations are quite similar to those reported in narcolepsy-cataplexy. Pharmacologically, systemic administration of alpha(2) adrenoceptor agonists increases gripping-induced IEs, whereas alpha(2) antagonists decrease them. However prazosin, an alpha(1) antagonist, increases gripping-induced IEs. In male 8-month-old taiep rats we have studied the effect of systemic administration of serotonergic autoreceptor agonists and antagonists on gripping-induced IEs. 8-Hydroxy-2-(di-n-propylamino) tetraline hydrobromide (8-OH-DPAT), a 5-HT(1A) agonist, and 3-trifluoromethylphenylpiperazine hydrochloride (TFMPP), a 5-HT(1B) agonist, produce a significant decrease in the frequency and mean duration of IEs. Systemic administration of spiperone and 1-(2-methoxyphenyl)-4[4-(2-phthalimido) butyl]piperazine hydrobromide (NAN-190), 5-HT(1) antagonists, increase IEs and their mean duration. When the specific serotonin antagonist N-[2[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide maleate (WAY 100635, 100 microg/kg) was injected 15 min before 8-OH-DPAT, this specific antagonist reverses the effects caused by the 5-HT(1A) agonist. These results show that serotonergic 5-HT(1)-receptors are involved in the susceptibility of gripping-induced IEs in taiep rats. Similar results have been reported in the food-elicited cataplexy test in narcoleptic dogs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Cataplexia / Agonistas do Receptor de Serotonina / Força da Mão / Agonistas do Receptor 5-HT1 de Serotonina / Narcolepsia Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2009 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Cataplexia / Agonistas do Receptor de Serotonina / Força da Mão / Agonistas do Receptor 5-HT1 de Serotonina / Narcolepsia Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2009 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda