A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation.
Science
; 326(5952): 575-8, 2009 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-19900895
Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate presynaptic development in the brain are largely unknown. We found that the major mitotic E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) regulates presynaptic differentiation in primary postmitotic mammalian neurons and in the rat cerebellar cortex. Cdc20-APC triggered the degradation of the transcription factor NeuroD2 and thereby promoted presynaptic differentiation. The NeuroD2 target gene encoding Complexin II, which acts locally at presynaptic sites, mediated the ability of NeuroD2 to suppress presynaptic differentiation. Thus, our findings define a Cdc20-APC ubiquitin signaling pathway that governs presynaptic development, which holds important implications for neuronal connectivity and plasticity in the brain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Sinapses
/
Transdução de Sinais
/
Terminações Pré-Sinápticas
/
Proteínas de Ciclo Celular
/
Ubiquitina
/
Complexos Ubiquitina-Proteína Ligase
/
Ubiquitina-Proteína Ligases
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos