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Acute and subchronic oral toxicities of Calendula officinalis extract in Wistar rats.
Lagarto, Alicia; Bueno, Viviana; Guerra, Isbel; Valdés, Odalys; Vega, Yamile; Torres, Leonid.
Afiliação
  • Lagarto A; Drug Research and Development Center, CIDEM, 17 No. 6208 e/ 62 y 64, Playa, Havana City, Cuba. cidem@infomed.sld.cu
Exp Toxicol Pathol ; 63(4): 387-91, 2011 May.
Article em En | MEDLINE | ID: mdl-20335011
We have studied the acute and subchronic oral toxicities of Calendula officinalis extract in male and female Wistar rats. A single acute C. officinalis extract dose of 2000 mg/kg dissolved in distilled water was administered by oral gavage for acute toxicity. Subchronic doses of 50, 250 and 1000 mg/kg/day were administered in drinking water. The major toxicological endpoints examined included animal body weight, water and food intake, selected tissue weights, and histopathological examinations. In addition, we examined blood elements: hematocrit, hemoglobin concentration, erythrocyte count, total and differential leukocyte count and blood clotting time and blood chemistry: glucose, total cholesterol, urea, total proteins, alkaline phosphatase, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In the acute study, there were no mortality and signs of toxicity. In the subchronic study, several of the blood elements were significantly affected in males and females after 90 days; hemoglobin, erythrocytes, leukocytes and blood clotting time. For blood chemistry parameters, ALT, AST and alkaline phosphatase were affected. Histopathological examination of tissues showed slight abnormalities in hepatic parenchyma that were consistent with biochemical variations observed. These studies indicate that the acute and subchronic toxicities of C. officinalis extract are low.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Calendula / Flores Limite: Animals Idioma: En Revista: Exp Toxicol Pathol Assunto da revista: PATOLOGIA / TOXICOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Calendula / Flores Limite: Animals Idioma: En Revista: Exp Toxicol Pathol Assunto da revista: PATOLOGIA / TOXICOLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha