Early alveolar bone regeneration in rats after topical administration of simvastatin.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 112(2): 170-9, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21194993
OBJECTIVES: The aim of this study was to ultrastructurally examine the influence of simvastatin on bone healing in surgically created defects in rat mandibles. STUDY DESIGN: Bone defects 0.8 mm in diameter were created in the buccal aspect of first mandibular molar roots and filled with 2.5% simvastatin gel, while the controls were allowed to heal spontaneously. The rats were humanely killed 7, 9, 11, or 14 days postoperatively, and the specimens were processed for scanning and transmission electron microscopy, as well as for colloidal gold immunolabeling of osteopontin. RESULTS: The regenerated alveolar bone in the simvastatin-treated defects presented smaller marrow spaces, and the collagen fibrils were regularly packed exhibiting a lamellar bone aspect. Osteopontin was present through the bone matrix during the wound healing and alveolar bone regeneration. CONCLUSION: The present study provides evidence that a single topical application of 2.5% simvastatin gel improves the quality of the new bone and decreases bone resorption.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração Óssea
/
Doenças Mandibulares
/
Perda do Osso Alveolar
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Sinvastatina
Limite:
Animals
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos