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An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors.
Kamila, Sukanta; Ankati, Haribabu; Biehl, Edward R.
Afiliação
  • Kamila S; Southern Methodist University, Department of, Chemistry, Dallas, TX, 75275.
Tetrahedron Lett ; 52(34): 4375-4377, 2011 Aug 24.
Article em En | MEDLINE | ID: mdl-21804651
(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indol-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxothiazolidine-4-ones were prepared from corresponding aromatic amines (1a-e) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acidchlorides (5a-d) using HSnBu(3).

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Tetrahedron Lett Ano de publicação: 2011 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Tetrahedron Lett Ano de publicação: 2011 Tipo de documento: Article País de publicação: Reino Unido