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SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine tumours (GEP NETS).
García-Carbonero, Rocío; Salazar, Ramón; Sevilla, Isabel; Isla, Dolores.
Afiliação
  • García-Carbonero R; Medical Oncology Department, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain. rgcarbonero@hotmail.com
Clin Transl Oncol ; 13(8): 545-51, 2011 Aug.
Article em En | MEDLINE | ID: mdl-21821488
Gastroenteropancreatic neuroendocrine tumours (GEP NETs) represent a heterogenous family of tumours with growing incidence and challenging clinical management. Unlike other solid tumours, they have the ability to secrete different peptides and neuramines that cause distinct clinical syndromes. However, many are clinically silent until advanced disease. This guideline aims to provide practical recommendations for the diagnosis and treatment of GEP NETs. Most recent histological and staging classifications, as well as available therapeutic approaches, such as surgery, locoregional therapy, peptide receptor radionuclide therapy (PRRT) and hormonal or systemic therapy, are discussed in this manuscript, including some recent relevant achievements with novel targeted agents. Clinical presentation (with or without hormonal syndrome), histological tumour features (including proliferation index (Ki-67) and the presence or not of somatostatin receptors), tumour stage, and location of primary tumour and distant metastasis are all key issues that shall be taken into consideration to properly design and integrate the most adequate therapeutic strategy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Tumores Neuroendócrinos / Oncologia Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Tumores Neuroendócrinos / Oncologia Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália