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Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.
Kabi, Amrita; Nickerson, Kourtney P; Homer, Craig R; McDonald, Christine.
Afiliação
  • Kabi A; Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Inflamm Bowel Dis ; 18(4): 782-92, 2012 Apr.
Article em En | MEDLINE | ID: mdl-21936032
The success of genetic analyses identifying multiple loci associated with inflammatory bowel disease (IBD) susceptibility has resulted in the identification of several risk genes linked to a common cellular process called autophagy. Autophagy is a process involving the encapsulation of cytosolic cellular components in double-membrane vesicles, their subsequent lysosomal degradation, and recycling of the degraded components for use by the cell. It plays an important part in the innate immune response to a variety of intracellular pathogens, and it is this component of autophagy that appears to be defective in IBD. This has lead to the hypothesis that Crohn's disease may result from an impaired antibacterial response, which leads to ineffective control of bacterial infection, dysbiosis of the intestinal microbiota, and chronic inflammation. Several recurrent themes have surfaced from studies examining the function of autophagy-related genes in the context of IBD, with cellular context, disease status, risk variant effect, and risk gene interplay all affecting the interpretation of these studies. The identification of autophagy as a major risk pathway in IBD is a significant step forward and may lead to pathway-focused therapy in the future; however, there is more to understand in order to unravel the complexity of this disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Fagossomos / Doenças Inflamatórias Intestinais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Fagossomos / Doenças Inflamatórias Intestinais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido