Your browser doesn't support javascript.
loading
Changes in autonomic control of the cardiovascular system in the Wistar audiogenic rat (WAR) strain.
Fazan, Rubens; de Oliveira, Mauro; Oliveira, José Antônio C; Salgado, Helio C; Garcia-Cairasco, Norberto.
Afiliação
  • Fazan R; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Epilepsy Behav ; 22(4): 666-70, 2011 Dec.
Article em En | MEDLINE | ID: mdl-22015213
We evaluated autonomic cardiovascular modulation and baroreflex control of heart rate (HR) in a particular epileptic rat strain, Wistar audiogenic rats (WARs). We studied spontaneous baroreflex sensitivity as well as reflex changes in HR evoked by phenylephrine/nitroprusside-induced changes in arterial pressure (AP). Atropine and propranolol were used to measure cardiac autonomic tone. AP and pulse interval (PI) variability analysis were performed in the time and frequency domains (FFT spectral analysis) to evaluate cardiovascular sympatovagal modulation in WARs. AP and HR were higher in WARs (109±2 mm Hg and 366±9 bpm) than in Wistar control rats (101±2 mm Hg and 326±10 bpm). The power of the low-frequency band of both AP and PI spectra, a marker of sympathetic modulation, was higher in WARs than in Wistar control rats. The high-frequency power of the PI spectra in normalized units, which is linked to cardiac vagal modulation, was lower in WARs. Both WARs and Wistar control rats had similar vagal tone (91±13 bpm vs 94±11 bpm, respectively), but sympathetic tone was higher in WARs (30±4 bpm vs 14±4 bpm). No differences were detected in the gain of evoked (1.32±0.1 ms/mm Hg vs 1.35±0.2 ms/mm Hg) or spontaneous (1.34±0.2 ms/mm Hg vs 2.04±0.2 ms/mm Hg) baroreflex sensitivity. The higher AP and HR and the autonomic imbalance (sympathetic predominance) in WARs might be associated with an increased risk of life-threatening cardiovascular events in this strain.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Epilepsia Reflexa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Epilepsia Reflexa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos