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The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.
Garavito, Giovanny; Bertani, Stéphane; Quiliano, Miguel; Valentin, Alexis; Aldana, Ignacio; Deharo, Eric.
Afiliação
  • Garavito G; Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.
Mem Inst Oswaldo Cruz ; 107(6): 820-3, 2012 Sep.
Article em En | MEDLINE | ID: mdl-22990975
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Malária / Azul de Metileno / Antimaláricos Limite: Animals Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Malária / Azul de Metileno / Antimaláricos Limite: Animals Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Brasil