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Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial.
Oncel, Mehmet Yekta; Yurttutan, Sadik; Erdeve, Omer; Uras, Nurdan; Altug, Nahide; Oguz, Serife Suna; Canpolat, Fuat Emre; Dilmen, Ugur.
Afiliação
  • Oncel MY; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. Electronic address: dryekta@gmail.com.
  • Yurttutan S; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
  • Erdeve O; Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey.
  • Uras N; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
  • Altug N; Division of Pediatric Cardiology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
  • Oguz SS; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
  • Canpolat FE; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
  • Dilmen U; Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey; Department of Pediatrics, Yildirim Beyazit University School of Medicine, Ankara, Turkey.
J Pediatr ; 164(3): 510-4.e1, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24359938
OBJECTIVE: To compare the efficacy and safety of oral paracetamol and oral ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants. STUDY DESIGN: This prospective, randomized, controlled study enrolled 90 preterm infants with gestational age ≤ 30 weeks, birthweight ≤ 1250 g, and postnatal age 48 to 96 hours who had echocardiographically confirmed significant PDA. Each enrolled patient received either oral paracetamol (15 mg/kg every 6 hours for 3 days) or oral ibuprofen (initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 hours). RESULTS: Spontaneous closure rate for the entire study group was 54%. After the first course of treatment, the PDA closed in 31 (77.5%) of the patients assigned to the oral ibuprofen group vs 29 (72.5%) of those enrolled in the oral paracetamol group (P = .6). The reopening rate was higher in the paracetamol group than in the ibuprofen group, but the reopening rates were not statistically different (24.1% [7 of 29] vs 16.1% [5 of 31]; P = .43). The cumulative closure rates after the second course of drugs were high in both groups. Only 2 patient (2.5%) in the paracetamol group and 3 patients (5%) in the ibuprofen group required surgical ligation. CONCLUSION: This randomized, controlled clinical study compared oral paracetamol with ibuprofen in preterm infants and demonstrated that paracetamol may be a medical alternative in the management of PDA.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ibuprofeno / Inibidores de Ciclo-Oxigenase / Permeabilidade do Canal Arterial / Acetaminofen Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies Limite: Humans / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ibuprofeno / Inibidores de Ciclo-Oxigenase / Permeabilidade do Canal Arterial / Acetaminofen Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies Limite: Humans / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos