A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems.

Massaoka, Mariana H; Matsuo, Alisson L; Figueiredo, Carlos R; Girola, Natalia; Faria, Camyla F; Azevedo, Ricardo A; Travassos, Luiz R

Massaoka, Mariana H; Matsuo, Alisson L; Figueiredo, Carlos R; Girola, Natalia; Faria, Camyla F; Azevedo, Ricardo A; Travassos, Luiz R.

Afiliação

Massaoka MH; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Matsuo AL; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Figueiredo CR; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Girola N; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Faria CF; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Azevedo RA; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.
Travassos LR; Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil.

FEBS Open Bio ; 4: 153-61, 2014.

Article em En | MEDLINE | ID: mdl-24490140

Palavras-chave

C PEP, control peptide; CL-ELISA, chemiluminescence ELISA; CPP, cell-penetrating peptide; Malignant melanoma; SA-ßGal, senescence-associated ß-galactosidase; Senescence; TMZ, Temozolomide; WT1, Wilms tumor protein 1; Wilms tumor 1 (WT1); ZF, zinc-finger; p53; pTj, Trojan peptide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: FEBS Open Bio Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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