A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design.

Davda, Jasmine P; Dodds, Michael G; Gibbs, Megan A; Wisdom, Wendy; Gibbs, John

Davda, Jasmine P; Dodds, Michael G; Gibbs, Megan A; Wisdom, Wendy; Gibbs, John.

Afiliação

Davda JP; 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA USA.
Dodds MG; 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA USA.
Gibbs MA; 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA USA.
Wisdom W; 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA USA.
Gibbs J; 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA USA.

MAbs ; 6(4): 1094-102, 2014.

Article em En | MEDLINE | ID: mdl-24837591

Assuntos

Anticorpos Monoclonais/farmacocinética; Anticorpos Monoclonais/uso terapêutico; Modelos Biológicos; Administração Intravenosa; Humanos; Injeções Subcutâneas; Processos Estocásticos

Palavras-chave

drug development; first in human; meta-analysis; monoclonal antibody; optimal design; population pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Biológicos / Anticorpos Monoclonais Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: MAbs Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article

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