A vapourized &#916;(9)-tetrahydrocannabinol (&#916;(9)-THC) delivery system part I: development and validation of a pulmonary cannabinoid route of exposure for experimental pharmacology studies in rodents.

Manwell, Laurie A; Charchoglyan, Armen; Brewer, Dyanne; Matthews, Brittany A; Heipel, Heather; Mallet, Paul E

A vapourized Δ(9)-tetrahydrocannabinol (Δ(9)-THC) delivery system part I: development and validation of a pulmonary cannabinoid route of exposure for experimental pharmacology studies in rodents.

Manwell, Laurie A; Charchoglyan, Armen; Brewer, Dyanne; Matthews, Brittany A; Heipel, Heather; Mallet, Paul E.

Afiliação

Manwell LA; Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L3C5, Canada; Department of Psychology, University of Guelph, Guelph, ON N1G2W1, Canada; Mass Spectrometry Facility, University of Guelph, Guelph, ON N1G2W1, Canada; Centre for Addiction and Mental Health, Social Aetiology of Menta
Charchoglyan A; Mass Spectrometry Facility, University of Guelph, Guelph, ON N1G2W1, Canada.
Brewer D; Mass Spectrometry Facility, University of Guelph, Guelph, ON N1G2W1, Canada.
Matthews BA; Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L3C5, Canada.
Heipel H; Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L3C5, Canada.
Mallet PE; Department of Psychology, Wilfrid Laurier University, Waterloo, ON N2L3C5, Canada.

J Pharmacol Toxicol Methods ; 70(1): 120-7, 2014.

Article em En | MEDLINE | ID: mdl-24973534

Assuntos

Canabinoides/administração & dosagem; Dronabinol/administração & dosagem; Administração por Inalação; Animais; Comportamento Animal/efeitos dos fármacos; Canabinoides/sangue; Canabinoides/farmacocinética; Cromatografia Líquida/métodos; Dronabinol/sangue; Dronabinol/farmacocinética; Sistemas de Liberação de Medicamentos/métodos; Injeções Intraperitoneais/métodos; Pulmão/efeitos dos fármacos; Masculino; Espectrometria de Massas/métodos; Modelos Animais; Morfina/administração & dosagem; Morfina/efeitos adversos; Ratos; Ratos Sprague-Dawley

Palavras-chave

11-hydroxy-Δ(9)-tetrahydrocannabinol (11-OH-THC); Liquid-chromatography/mass spectrometry (LC/MS); Plasma; Pulmonary administration; Rat; Whole blood; Δ(9)-tetrahydrocannabinol (THC)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dronabinol / Canabinoides Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos

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