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BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.
Fiskus, Warren; Sharma, Sunil; Qi, Jun; Shah, Bhavin; Devaraj, Santhana G T; Leveque, Christopher; Portier, Bryce P; Iyer, Swaminathan; Bradner, James E; Bhalla, Kapil N.
Afiliação
  • Fiskus W; Baylor College of Medicine, Houston, Texas.
  • Sharma S; University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah.
  • Qi J; Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Shah B; Houston Methodist Research Institute, Houston, Texas.
  • Devaraj SG; Houston Methodist Research Institute, Houston, Texas.
  • Leveque C; Houston Methodist Research Institute, Houston, Texas.
  • Portier BP; Houston Methodist Research Institute, Houston, Texas.
  • Iyer S; Houston Methodist Research Institute, Houston, Texas.
  • Bradner JE; Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Bhalla KN; Houston Methodist Research Institute, Houston, Texas. knbhalla@tmhs.org.
Mol Cancer Ther ; 13(10): 2315-27, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25053825

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azepinas / Triazóis / Leucemia Mieloide Aguda Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azepinas / Triazóis / Leucemia Mieloide Aguda Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos