Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni.
Hum Vaccin Immunother
; 11(3): 601-19, 2015.
Article
em En
| MEDLINE
| ID: mdl-25715096
In Part II we discuss the following bacterial pathogens: Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic) and Campylobacter jejuni. In contrast to the enteric viruses and Vibrio cholerae discussed in Part I of this series, for the bacterial pathogens described here there is only one licensed vaccine, developed primarily for Vibrio cholerae and which provides moderate protection against enterotoxigenic E. coli (ETEC) (Dukoral(®)), as well as a few additional candidates in advanced stages of development for ETEC and one candidate for Shigella spp. Numerous vaccine candidates in earlier stages of development are discussed.
Palavras-chave
CFU, colony-forming units; CFs, colonization factors; CT, cholera toxin; CT-B cholera toxin B subunit; Campylobacter; CtdB, cytolethal distending toxin subunit B; E. coli; EHEC; EPEC, enteropathogenic E. coli; ETEC; ETEC, enterotoxigenic E. coli; GEMS, Global enterics multicenter study; HUS, hemolytic uremic syndrome; IM, intramuscular; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; LEE, locus of enterocyte effacement; LPS, lipopolysaccharide; LT, heat labile toxin; LT-B; OMV, outer membrane vesicles; ST, heat stable toxin; STEC; STEC, shigatoxin producing E. coli; STh, human heat stable toxin; STp, porcine heat stable toxin; Salmonella; Shigella; Stx, shigatoxin; TTSS, type III secretion system; V. cholera; WHO, World Health Organization; acute diarrhea; dmLT, double mutant heat labile toxin; enteric pathogens; enterohemorrhagic E. coli; gastroenteritis; heat labile toxin B subunit; norovirus; rEPA, recombinant exoprotein A of Pseudomonas aeruginosa; rotavirus; vaccines
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salmonella
/
Shigella
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Vacinas Bacterianas
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Campylobacter jejuni
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Diarreia
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Escherichia coli
/
Gastroenterite
Limite:
Humans
Idioma:
En
Revista:
Hum Vaccin Immunother
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Estados Unidos