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First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Eng, Wai Soon; Hocková, Dana; Spacek, Petr; Janeba, Zlatko; West, Nicholas P; Woods, Kyra; Naesens, Lieve M J; Keough, Dianne T; Guddat, Luke W.
Afiliação
  • Eng WS; †The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia.
  • Hocková D; ‡Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nam. 2, CZ-166 10 Prague 6, Czech Republic.
  • Spacek P; ‡Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nam. 2, CZ-166 10 Prague 6, Czech Republic.
  • Janeba Z; ‡Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nam. 2, CZ-166 10 Prague 6, Czech Republic.
  • West NP; †The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia.
  • Woods K; †The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia.
  • Naesens LM; §Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
  • Keough DT; †The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia.
  • Guddat LW; †The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia.
J Med Chem ; 58(11): 4822-38, 2015 Jun 11.
Article em En | MEDLINE | ID: mdl-25915781
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Pró-Fármacos / Guanosina Monofosfato / Difosfatos / Organofosfonatos / Hipoxantina Fosforribosiltransferase / Mycobacterium tuberculosis / Antituberculosos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Pró-Fármacos / Guanosina Monofosfato / Difosfatos / Organofosfonatos / Hipoxantina Fosforribosiltransferase / Mycobacterium tuberculosis / Antituberculosos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos