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[Cell signaling pathways interaction in cellular proliferation: Potential target for therapeutic interventionism]. / Interacción de las vías de señalización intracelulares participantes en la proliferación celular: potencial blanco de intervencionismo terapéutico.
Valdespino-Gómez, Víctor Manuel; Valdespino-Castillo, Patricia Margarita; Valdespino-Castillo, Víctor Edmundo.
Afiliação
  • Valdespino-Gómez VM; Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco de la Ciudad de México, Ciudad de México, México. Electronic address: vvaldespinog@yahoo.com.mx.
  • Valdespino-Castillo PM; Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, México.
  • Valdespino-Castillo VE; Unidad Médica de Atención Ambulatoria, Instituto Mexicano del Seguro Social, Campeche, Campeche, México.
Cir Cir ; 83(2): 165-74, 2015.
Article em Es | MEDLINE | ID: mdl-25986976
Nowadays, cellular physiology is best understood by analysing their interacting molecular components. Proteins are the major components of the cells. Different proteins are organised in the form of functional clusters, pathways or networks. These molecules are ordered in clusters of receptor molecules of extracellular signals, transducers, sensors and biological response effectors. The identification of these intracellular signaling pathways in different cellular types has required a long journey of experimental work. More than 300 intracellular signaling pathways have been identified in human cells. They participate in cell homeostasis processes for structural and functional maintenance. Some of them participate simultaneously or in a nearly-consecutive progression to generate a cellular phenotypic change. In this review, an analysis is performed on the main intracellular signaling pathways that take part in the cellular proliferation process, and the potential use of some components of these pathways as target for therapeutic interventionism are also underlined.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proliferação de Células Limite: Humans Idioma: Es Revista: Cir Cir Ano de publicação: 2015 Tipo de documento: Article País de publicação: México

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proliferação de Células Limite: Humans Idioma: Es Revista: Cir Cir Ano de publicação: 2015 Tipo de documento: Article País de publicação: México