Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds.

Lei, Kang; Hua, Xue-Wen; Tao, Yuan-Yuan; Liu, Yang; Liu, Na; Ma, Yi; Li, Yong-Hong; Xu, Xiao-Hua; Kong, Chui-Hua

Lei, Kang; Hua, Xue-Wen; Tao, Yuan-Yuan; Liu, Yang; Liu, Na; Ma, Yi; Li, Yong-Hong; Xu, Xiao-Hua; Kong, Chui-Hua.

Afiliação

Lei K; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
Hua XW; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
Tao YY; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
Liu Y; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
Liu N; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
Ma Y; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China.
Li YH; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China.
Xu XH; State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China. Electronic address: xiaohuaxu@nankai.edu.cn.
Kong CH; College of Resources and Environmental Sciences, China Agricultural University, Beijing, China.

Bioorg Med Chem ; 24(2): 92-103, 2016 Jan 15.

Article em En | MEDLINE | ID: mdl-26682702

Assuntos

4-Hidroxifenilpiruvato Dioxigenase/antagonistas & inibidores; Arabidopsis/enzimologia; Óxidos S-Cíclicos/farmacologia; Descoberta de Drogas; Herbicidas/farmacologia; Tiazinas/farmacologia; 4-Hidroxifenilpiruvato Dioxigenase/metabolismo; Amaranthus/efeitos dos fármacos; Arabidopsis/efeitos dos fármacos; Brassica/efeitos dos fármacos; Óxidos S-Cíclicos/química; Relação Dose-Resposta a Droga; Echinochloa/efeitos dos fármacos; Herbicidas/síntese química; Herbicidas/química; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Tiazinas/síntese química; Tiazinas/química

Palavras-chave

4-Hydroxyphenylpyruvate dioxygenase; Benzothiazine; Herbicide activity; Structureactivity relationships; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazinas / Arabidopsis / Óxidos S-Cíclicos / Descoberta de Drogas / Herbicidas / 4-Hidroxifenilpiruvato Dioxigenase Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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