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Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus).
Pereira, Thiago Scremin Boscolo; Boscolo, Camila Nomura Pereira; Felício, Andreia Arantes; Batlouni, Sergio Ricardo; Schlenk, Daniel; de Almeida, Eduardo Alves.
Afiliação
  • Pereira TS; Department of Zoology and Botany, Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP - 15054-000, São José do Rio Preto, SP, Brazil.
  • Boscolo CN; Department of Zoology and Botany, Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP - 15054-000, São José do Rio Preto, SP, Brazil.
  • Felício AA; Department of Chemistry and Environmental Sciences, Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP - 15054-000, São José do Rio Preto, SP, Brazil.
  • Batlouni SR; Aquaculture Center, Universidade Estadual Paulista (CAUNESP), Via de Acesso Prof. Paulo Donato Castelane, s/n., CEP - 14884-900, Jaboticabal, SP, Brazil.
  • Schlenk D; Department of Environmental Sciences, University of California, Riverside, 3401Watkins Dr, Riverside, CA 92521, USA.
  • de Almeida EA; Department of Chemistry and Environmental Sciences, Universidade Estadual Paulista (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP - 15054-000, São José do Rio Preto, SP, Brazil. Electronic address: ealmeida@ibilce.unesp.br.
Chemosphere ; 146: 497-502, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26741556
Some endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary-gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17α-hydroxyprogesterone (17α-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Monitoramento Ambiental / Tilápia / Diurona / Estradiol / Disruptores Endócrinos Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Chemosphere Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Monitoramento Ambiental / Tilápia / Diurona / Estradiol / Disruptores Endócrinos Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Chemosphere Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido