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Effect of incorporating antifungals on the water sorption and solubility of interim resilient liners for denture base relining.
Lima, Jozely F M; Maciel, Janaina G; Arrais, César A G; Porto, Vinícius C; Urban, Vanessa M; Neppelenbroek, Karin H.
Afiliação
  • Lima JF; Postgraduate student, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Maciel JG; Postgraduate student, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Arrais CA; Assistant Professor, Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
  • Porto VC; Associate Professor, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Urban VM; Assistant Professor, Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil. Electronic address: vanurban@yahoo.com.
  • Neppelenbroek KH; Assistant Professor, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
J Prosthet Dent ; 115(5): 611-6, 2016 May.
Article em En | MEDLINE | ID: mdl-26794705
STATEMENT OF PROBLEM: Incorporating antifungals into interim denture resilient liners has been proposed to prolong their clinical longevity and to treat denture stomatitis. However, information is lacking on the effect of this addition on water sorption and solubility. PURPOSE: The purpose of this in vitro study was to evaluate the addition of minimum inhibitory concentrations (MICs) of antifungals for Candida albicans biofilm on the water sorption (WS) and solubility of interim denture resilient liners. MATERIAL AND METHODS: Disk-shaped specimens (n=10; 50×0.5 mm) of tissue conditioner (Softone) and resilient liner (Trusoft) were created either without (control) or with the incorporation of 1 of the 3 following drugs at MICs (g of drug per g of resilient material powder): nystatin (Ny, 0.032g/g), chlorhexidine diacetate (Chx, 0.064g/g), and ketoconazole (Ke, 0.128g/g). Specimens were dried; immersed in water for 24 hours and 7 or 14 days; weighed, dried, and weighed again. Data (µg/mm(3)) were analyzed by 3-way ANOVA followed by the Tukey-Kramer honest significant differences test (α=.05). RESULTS: At the 14-day interval, only the addition of Chx (483.0 ±61.0 µg/mm(3)) increased the WS of the tissue conditioner compared with the control group (244.0 ±42.0 µg/mm(3); P<.001). For all periods, the solubility of both materials increased with the addition of Chx (27.7 ±6.1 µg/mm(3)) and Ke (30.9 ±5.3 µg/mm(3)) compared with the control group (22.5 ±6.0 µg/mm(3); P<.001). CONCLUSIONS: After 14 days, the addition of Ny and Ke at MICs in both Softone and Trusoft and addition of Chx in Trusoft did not affect WS. The solubility of the 2 interim materials was not altered by the addition of Ny for up to 14 days.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bases de Dentadura / Reembasamento de Dentadura / Antifúngicos Limite: Humans Idioma: En Revista: J Prosthet Dent Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bases de Dentadura / Reembasamento de Dentadura / Antifúngicos Limite: Humans Idioma: En Revista: J Prosthet Dent Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos