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Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors.
Liang, Xuewu; Huang, Yongxue; Zang, Jie; Gao, Qianwen; Wang, Binghe; Xu, Wenfang; Zhang, Yingjie.
Afiliação
  • Liang X; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Huang Y; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Zang J; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Gao Q; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Wang B; Georgia Research Alliance Eminent Scholar in Drug Discovery, Department of Chemistry, Georgia State University, United States. Electronic address: chebw@langate.gsu.edu.
  • Xu W; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, PR China. Electronic address: zhangyingjie@sdu.edu.cn.
Bioorg Med Chem ; 24(12): 2660-72, 2016 06 15.
Article em En | MEDLINE | ID: mdl-27137359
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Janus Quinases Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Janus Quinases Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido