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A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.
Kromann-Hansen, Tobias; Oldenburg, Emil; Yung, Kristen Wing Yu; Ghassabeh, Gholamreza H; Muyldermans, Serge; Declerck, Paul J; Huang, Mingdong; Andreasen, Peter A; Ngo, Jacky Chi Ki.
Afiliação
  • Kromann-Hansen T; From the Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark, tobiaskh@mbg.au.dk.
  • Oldenburg E; From the Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark.
  • Yung KW; the School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
  • Ghassabeh GH; the Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussels, 1050 Brussels, Belgium, Nanobody Service Facility, Flanders Institute for Biotechnology, 1050 Brussels, Belgium.
  • Muyldermans S; the Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussels, 1050 Brussels, Belgium.
  • Declerck PJ; the Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit, 3000 Leuven, Belgium, and.
  • Huang M; the State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, Fuzhou, Fujian 350002, China.
  • Andreasen PA; From the Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark.
  • Ngo JC; the School of Life Sciences, Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
J Biol Chem ; 291(29): 15156-68, 2016 07 15.
Article em En | MEDLINE | ID: mdl-27226628
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camelídeos Americanos / Serina Proteases / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camelídeos Americanos / Serina Proteases / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos