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Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice.
Zhang, Zhen; Song, Yuejia; Zhang, Ze; Li, Danyang; Zhu, Hong; Liang, Rui; Gu, Yunhe; Pang, Yuxin; Qi, Jiping; Wu, He; Wang, Jian.
Afiliação
  • Zhang Z; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Song Y; Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Zhang Z; Department of Urology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Li D; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Zhu H; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Liang R; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Gu Y; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Pang Y; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
  • Qi J; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China wuher_2008@hotmail.com qijiping2003@163.com.
  • Wu H; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, PR China wuher_2008@hotmail.com qijiping2003@163.com.
  • Wang J; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
J Cereb Blood Flow Metab ; 37(1): 25-38, 2017 01.
Article em En | MEDLINE | ID: mdl-27317654
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. Heme oxygenase-1 (HO-1), the key enzyme in heme degradation, is highly expressed after ICH, but its role is still unclear. In this study, we used an HO-1 inducer and inhibitor to test the role of HO-1 in different stages of ICH in vivo and in vitro. In the early stage of ICH, high HO-1 expression worsened the outcomes of mice subjected to the collagenase-induced ICH model. HO-1 increased brain edema, white matter damage, neuronal death, and neurobehavioral deficits. Furthermore, elevated HO-1 increased inflammation, oxidative stress, matrix metalloproteinase-9/2 activity, and iron deposition. In the later stage of ICH, long-term induction of HO-1 increased hematoma absorption, angiogenesis, and recovery of neurologic function. We conclude that HO-1 activation mediates early brain damage after ICH but promotes neurologic function recovery in the later stage of ICH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Heme Oxigenase-1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Heme Oxigenase-1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos