AMA0428, A Potent Rock Inhibitor, Attenuates Early and Late Experimental Diabetic Retinopathy.

Hollanders, Karolien; Hove, Inge Van; Sergeys, Jurgen; Bergen, Tine Van; Lefevere, Evy; Kindt, Nele; Castermans, Karolien; Vandewalle, Evelien; van Pelt, Jos; Moons, Lieve; Stalmans, Ingeborg

Hollanders, Karolien; Hove, Inge Van; Sergeys, Jurgen; Bergen, Tine Van; Lefevere, Evy; Kindt, Nele; Castermans, Karolien; Vandewalle, Evelien; van Pelt, Jos; Moons, Lieve; Stalmans, Ingeborg.

Afiliação

Hollanders K; a Department of Ophthalmology , KU Leuven-University of Leuven , Leuven , Belgium.
Hove IV; b Department of Ophthalmology , University Hospitals Ghent , Ghent , Belgium.
Sergeys J; a Department of Ophthalmology , KU Leuven-University of Leuven , Leuven , Belgium.
Bergen TV; c Department of Biology, KU Leuven-University of Leuven , Leuven , Belgium.
Lefevere E; a Department of Ophthalmology , KU Leuven-University of Leuven , Leuven , Belgium.
Kindt N; c Department of Biology, KU Leuven-University of Leuven , Leuven , Belgium.
Castermans K; a Department of Ophthalmology , KU Leuven-University of Leuven , Leuven , Belgium.
Vandewalle E; a Department of Ophthalmology , KU Leuven-University of Leuven , Leuven , Belgium.
van Pelt J; c Department of Biology, KU Leuven-University of Leuven , Leuven , Belgium.
Moons L; d Amakem NV , Diepenbeek , Belgium.
Stalmans I; d Amakem NV , Diepenbeek , Belgium.

Curr Eye Res ; 42(2): 260-272, 2017 02.

Article em En | MEDLINE | ID: mdl-27399806

Assuntos

Retinopatia Diabética/tratamento farmacológico; Inibidores Enzimáticos/farmacologia; Retina/patologia; Quinases Associadas a rho/antagonistas & inibidores; Animais; Western Blotting; Células Cultivadas; Diabetes Mellitus Experimental; Retinopatia Diabética/metabolismo; Retinopatia Diabética/patologia; Progressão da Doença; Ensaio de Imunoadsorção Enzimática; Imuno-Histoquímica; Masculino; Camundongos; NF-kappa B/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Anti-vascular endothelial growth factor; diabetic retinopathy; oxygen-induced retinopathy model; rho kinase inhibition; streptozotocin-induced retinopathy model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retina / Retinopatia Diabética / Inibidores Enzimáticos / Quinases Associadas a rho Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Curr Eye Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Reino Unido

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