Your browser doesn't support javascript.
loading
Neurexin regulates nighttime sleep by modulating synaptic transmission.
Tong, Huawei; Li, Qian; Zhang, Zi Chao; Li, Yi; Han, Junhai.
Afiliação
  • Tong H; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
  • Li Q; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
  • Zhang ZC; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
  • Li Y; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
  • Han J; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.
Sci Rep ; 6: 38246, 2016 12 01.
Article em En | MEDLINE | ID: mdl-27905548
Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila α-neurexin homolog significantly reduces the quantity and quality of nighttime sleep and impairs sleep homeostasis. We report that neurexin expression in Drosophila mushroom body (MB) αß neurons is essential for nighttime sleep. We demonstrate that reduced nighttime sleep in neurexin mutants is due to impaired αß neuronal output, and show that neurexin functionally couples calcium channels (Cac) to regulate synaptic transmission. Finally, we determine that αß surface (αßs) neurons release both acetylcholine and short neuropeptide F (sNPF), whereas αß core (αßc) neurons release sNPF to promote nighttime sleep. Our findings reveal that neurexin regulates nighttime sleep by mediating the synaptic transmission of αß neurons. This study elucidates the role of synaptic transmission in sleep regulation, and might offer insights into the mechanism of sleep disturbances in patients with autism disorders.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Moléculas de Adesão Celular Neuronais / Transmissão Sináptica / Corpos Pedunculados / Proteínas de Drosophila / Sonhos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Moléculas de Adesão Celular Neuronais / Transmissão Sináptica / Corpos Pedunculados / Proteínas de Drosophila / Sonhos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido