Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.

Eiden, Carter G; Maize, Kimberly M; Finzel, Barry C; Lipscomb, John D; Aldrich, Courtney C

Eiden, Carter G; Maize, Kimberly M; Finzel, Barry C; Lipscomb, John D; Aldrich, Courtney C.

Afiliação

Eiden CG; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Maize KM; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Finzel BC; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Lipscomb JD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Aldrich CC; Department of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.

J Am Chem Soc ; 139(21): 7132-7135, 2017 05 31.

Article em En | MEDLINE | ID: mdl-28510452

Assuntos

Proteínas de Bactérias/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Mycobacterium tuberculosis/enzimologia; Piridonas/farmacologia; Transaminases/antagonistas & inibidores; Proteínas de Bactérias/metabolismo; Inibidores Enzimáticos/química; Cinética; Estrutura Molecular; Piridonas/química; Transaminases/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Proteínas de Bactérias / Inibidores Enzimáticos / Transaminases / Mycobacterium tuberculosis Idioma: En Revista: J Am Chem Soc Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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