Impact of HLA-DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort.
HLA
; 90(4): 234-237, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28677168
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Infecções por HIV
/
Homossexualidade Masculina
/
Alelos
/
Cadeias HLA-DRB1
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Peru
Idioma:
En
Revista:
HLA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Reino Unido