Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.

Gu, Xiaoying; Gu, Dongfeng; He, Jiang; Rao, Dabeeru C; Hixson, James E; Chen, Jichun; Li, Jianxin; Huang, Jianfeng; Wu, Xigui; Rice, Treva K; Shimmin, Lawrence C; Kelly, Tanika N

Gu, Xiaoying; Gu, Dongfeng; He, Jiang; Rao, Dabeeru C; Hixson, James E; Chen, Jichun; Li, Jianxin; Huang, Jianfeng; Wu, Xigui; Rice, Treva K; Shimmin, Lawrence C; Kelly, Tanika N.

Afiliação

Gu X; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gu D; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine and School of Medicine, New Orleans, Louisiana, USA.
He J; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Rao DC; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine and School of Medicine, New Orleans, Louisiana, USA.
Hixson JE; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Chen J; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA.
Li J; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huang J; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wu X; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Rice TK; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shimmin LC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Kelly TN; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA.

Am J Hypertens ; 31(2): 205-211, 2018 01 12.

Article em En | MEDLINE | ID: mdl-29036630

Assuntos

Pressão Sanguínea/genética; Canais Epiteliais de Sódio/genética; Hipertensão; Cloreto de Sódio na Dieta/metabolismo; Adulto; Determinação da Pressão Arterial; Feminino; Predisposição Genética para Doença; Humanos; Hipertensão/metabolismo; Hipertensão/fisiopatologia; Masculino; Polimorfismo de Nucleotídeo Único

Palavras-chave

blood pressure; capillary-based sequencing; dietary sodium; epithelial 1 alpha subunit (SCNN1A); genetics; hypertension; mean arterial pressure; rare variants; salt sensitivity; single nucleotide polymorphism; sodium channel epithelial 1 beta subunit (SCNN1B); sodium channel epithelial 1 gamma subunit (SCNN1G)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Cloreto de Sódio na Dieta / Canais Epiteliais de Sódio / Hipertensão Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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