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A Randomized Trial of Conditioned or Unconditioned Gases for Stabilizing Preterm Infants at Birth.
McGrory, Lorraine; Owen, Louise S; Thio, Marta; Dawson, Jennifer A; Rafferty, Anthony R; Malhotra, Atul; Davis, Peter G; Kamlin, C Omar F.
Afiliação
  • McGrory L; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; Department of Child Health, The University of Dundee, Dundee, United Kingdom. Electronic address: lorraine.mcgrory@icloud.com.
  • Owen LS; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; The Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
  • Thio M; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; The Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
  • Dawson JA; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; The Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
  • Rafferty AR; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia.
  • Malhotra A; Monash Newborn, Monash Children's Hospital, Melbourne, Australia; Department of Pediatrics, Monash University, Melbourne, Australia.
  • Davis PG; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; The Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
  • Kamlin COF; Department of Newborn Research, The Royal Women's Hospital, Melbourne, Australia; The Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia.
J Pediatr ; 193: 47-53, 2018 02.
Article em En | MEDLINE | ID: mdl-29106924
OBJECTIVE: To determine whether the use of heated-humidified gases for respiratory support during the stabilization of infants <30 weeks of gestational age (GA) in the delivery room reduces rates of hypothermia on admission to the neonatal intensive care unit (NICU). STUDY DESIGN: A multicenter, unblinded, randomized trial was conducted in Melbourne, Australia, between February 2013 and June 2015. Infants <30 weeks of GA were randomly assigned to receive either heated-humidified gases or unconditioned gases during stabilization in the delivery room and during transport to NICU. Infants born to mothers with pyrexia >38°C were excluded. Primary outcome was rate of hypothermia on NICU admission (rectal temperature <36.5°C). RESULTS: A total of 273 infants were enrolled. Fewer infants in the heated-humidified group were hypothermic on admission to NICU (36/132 [27%]) compared with controls (61/141 [43%], P < .01). There was no difference in rates of hyperthermia (>37.5°C); 20% (27/132) in the heated-humidified group compared with 16% (22/141) in the controls (P = .30). There were no differences in mortality or respiratory outcomes. CONCLUSIONS: The use of heated-humidified gases in the delivery room significantly reduces hypothermia on admission to NICU in preterm infants, without increased risk of hyperthermia. CLINICAL TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Register (www.anzctr.org.au) ACTRN12613000093785.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Respiratória / Gases / Hipotermia Tipo de estudo: Clinical_trials Limite: Female / Humans / Male / Newborn País/Região como assunto: Oceania Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Respiratória / Gases / Hipotermia Tipo de estudo: Clinical_trials Limite: Female / Humans / Male / Newborn País/Região como assunto: Oceania Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos