Glut3 Addiction: A Druggable Vulnerability in Glioblastoma.

Bunda, Severa; Zadeh, Gelareh; Aldape, Kenneth D

Bunda, Severa; Zadeh, Gelareh; Aldape, Kenneth D.

Afiliação

Bunda S; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Zadeh G; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Aldape KD; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address: kaldape@gmail.com.

Cancer Cell ; 32(6): 726-727, 2017 12 11.

Article em En | MEDLINE | ID: mdl-29232550

RESUMO

The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.

Assuntos

Neoplasias Encefálicas; Glioblastoma; Adulto; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Limite: Adult / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos

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