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Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification.
Guo, Fengmin; Yue, Zekun; Trajkovski, Marko; Zhou, Xiaoping; Cao, Dong; Li, Qiang; Wang, Baifan; Wen, Xin; Plavec, Janez; Peng, Qian; Xi, Zhen; Zhou, Chuanzheng.
Afiliação
  • Guo F; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Yue Z; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Trajkovski M; Slovenian NMR Centre, National Institute of Chemistry , University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, EN-FIST Centre of Excellence , Hajdrihova 19 , Ljubljana 1000 , Slovenia.
  • Zhou X; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Cao D; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Li Q; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Wang B; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Wen X; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Plavec J; Slovenian NMR Centre, National Institute of Chemistry , University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, EN-FIST Centre of Excellence , Hajdrihova 19 , Ljubljana 1000 , Slovenia.
  • Peng Q; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Xi Z; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
  • Zhou C; State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry , Nankai University , Tianjin 300071 , China.
J Am Chem Soc ; 140(38): 11893-11897, 2018 09 26.
Article em En | MEDLINE | ID: mdl-30207719
RNA cleavage via internal transesterification is a fundamental reaction involved in RNA processing and metabolism, and the regulation thereof. Herein, the influence of ribose conformation on this reaction was investigated with conformationally constrained ribonucleotides. RNA cleavage rates were found to decrease in the order South-constrained ribonucleotide > native ribonucleotide ≫ North-constrained counterpart, indicating that the ribose conformation plays an important role in modulating RNA cleavage via internal transesterification.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligorribonucleotídeos / Ribose / RNA / Clivagem do RNA Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligorribonucleotídeos / Ribose / RNA / Clivagem do RNA Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos