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Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women.
Basurto, Lourdes; Gregory, Michael A; Hernández, Susana Barrera; Sánchez-Huerta, Lucero; Martínez, Alma Díaz; Manuel-Apolinar, Leticia; Avelar, Francisco J; Alonso, Laura Alejandra Mejía; Sánchez-Arenas, Rosalinda.
Afiliação
  • Basurto L; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Gregory MA; School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address: gregom2@mcmaster.ca.
  • Hernández SB; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Sánchez-Huerta L; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Martínez AD; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Manuel-Apolinar L; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Avelar FJ; Departament of Radiology, Hospital de Especialidades, Centro Médico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: francisco.avelar@imss.gob.mx.
  • Alonso LAM; Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico.
  • Sánchez-Arenas R; Research Unit in Epidemiology and Health Services, Centro Medico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: felicitasarenas@gmail.com.
Exp Gerontol ; 124: 110624, 2019 09.
Article em En | MEDLINE | ID: mdl-31152776
BACKGROUND: Atherosclerosis is a primary risk factor for cardiovascular disease (CVD). Proinflammatory biochemical factors can influence vascular health; monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with CVD while fibroblast growth factor-21 (FGF-21) acts directly on cardiac tissue to reduce infarction damage. However, the relationship between plasma concentrations of MCP-1, FGF-21 and subclinical CVD indices remains equivocal. AIM: To determine the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD. METHODS: A cross-sectional analysis of 140 women without history of CVD was performed. Anthropometrics were collected, serum concentrations of MCP-1 and FGF-21 were determined by enzyme-linked immunosorbent assay, and cIMT was quantified (B-mode ultrasonography). The correlations between MCP-1, FGF-21 and the presence of clinical and laboratory of subclinical atherosclerosis (i.e., cIMT ≥0.70 mm), comparison intergroup and odd ratio with multiple logistic regression were analyzed. RESULTS: MCP-1, but not FGF-21 correlated with some obesity indicators. In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21. In postmenopausal women, there were significant differences MCP-1 (p = 0.001), and FGF-21 (p = 0.010). Multiple logistic regression analysis in postmenopausal women with subclinical atherosclerosis, between MCP-1 (p = 0.001) and FGF-21 (p = 0.037) showed association with cIMT, along with age. CONCLUSIONS: MCP-1 and FGF-21 levels are associated with subclinical atherosclerosis disease severity (i.e., cIMT) in postmenopausal women without CVD. Further efforts focused on characterizing the relationship between novel blood-borne markers of early CVD pathology are warranted and should be pursued.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pós-Menopausa / Quimiocina CCL2 / Aterosclerose / Fatores de Crescimento de Fibroblastos Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Exp Gerontol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pós-Menopausa / Quimiocina CCL2 / Aterosclerose / Fatores de Crescimento de Fibroblastos Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Exp Gerontol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido