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Copper-Catalyzed Three-Component Difunctionalization of Aromatic Alkenes with 2-Amino-1,4-naphthoquinones and α-Bromocarboxylates.
Shangguan, Yu; Yang, Fazhou; Deng, Hao; Liu, Hao; Liu, Ziyan; Zhuang, Wanyue; Qiao, Chenxi; Wang, Aizheng; Xiao, Yumei; Zhang, Cheng.
Afiliação
  • Shangguan Y; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Yang F; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Deng H; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Liu H; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Liu Z; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Zhuang W; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Qiao C; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Wang A; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Xiao Y; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
  • Zhang C; Department of Applied Chemistry , China Agricultural University , 2 Yuanmingyuan West Road , Beijing 100193 , China.
J Org Chem ; 84(17): 10649-10657, 2019 09 06.
Article em En | MEDLINE | ID: mdl-31356065
A copper-catalyzed three-component difunctionalization of aromatic alkenes to access 1,4-naphthoquinone derivatives with diverse structures is described. Experiments show that the difunctionalization reaction is accompanied by ester exchange reaction with the solvent. In this method, α-bromocarboxylates are used as radical precursors and 2-amino-1,4-naphthoquinones as radical trapping reagents. The substrate scope is broad because various aromatic alkenes, 2-amino-1,4-naphthoquinones, and α-bromocarboxylates are employed in the reaction, and corresponding products are obtained in moderate to good yields.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos