Significant Value of 11C-Acetate and 18F-Fluorodeoxyglucose PET/Computed Tomography on 90Y Microsphere Radioembolization for Hepatocellular Carcinoma.

Ho, Chi Lai; Chen, Sirong; Cheung, Shing Kee; Leung, Thomas Wai Tong

Significant Value of ¹¹C-Acetate and ¹⁸F-Fluorodeoxyglucose PET/Computed Tomography on ⁹⁰Y Microsphere Radioembolization for Hepatocellular Carcinoma.

Ho, Chi Lai; Chen, Sirong; Cheung, Shing Kee; Leung, Thomas Wai Tong.

Afiliação

Ho CL; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China. Electronic address: garrettho@hksh.com.
Chen S; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China; Medical Physics & Research Department, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China.
Cheung SK; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China.
Leung TWT; Comprehensive Oncology Center, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China. Electronic address: Thomas.WT.Leung@hksh.com.

PET Clin ; 14(4): 459-467, 2019 Oct.

Article em En | MEDLINE | ID: mdl-31472743

RESUMO

Pretreatment dual-tracer (18F-fluorodeoxyglucose and 11C-acetate) PET/computed tomography (CT) has potential to predict treatment response for 90Y microsphere radioembolization (RE) in patients with inoperable hepatocellular carcinoma (HCC). Patients with 11C-acetate-avid HCC have a better response to 90Y microsphere RE, and possibly better survival. Pretreatment dual-tracer PET/CT has a significant theranostic value on 90Y microsphere RE in determining target tumor dose for HCCs with different cellular differentiation, metabolic tumor volume, and functioning liver volume, and can be used to prescribe individual injected activity of 90Y microspheres.

Assuntos

Braquiterapia/métodos; Carcinoma Hepatocelular/diagnóstico por imagem; Carcinoma Hepatocelular/radioterapia; Fluordesoxiglucose F18; Neoplasias Hepáticas/diagnóstico por imagem; Neoplasias Hepáticas/radioterapia; Acetatos/farmacologia; Carcinoma Hepatocelular/mortalidade; Feminino; Seguimentos; Humanos; Neoplasias Hepáticas/mortalidade; Masculino; Microesferas; Monitorização Fisiológica/métodos; Invasividade Neoplásica/patologia; Estadiamento de Neoplasias; Seleção de Pacientes; Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos; Dosagem Radioterapêutica; Medição de Risco; Resultado do Tratamento; Radioisótopos de Ítrio/uso terapêutico

Palavras-chave

(11)C-acetate; (18)F-FDG; (90)Y microspheres; HCC; PET/CT; Radioembolization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Braquiterapia / Carcinoma Hepatocelular / Fluordesoxiglucose F18 / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: PET Clin Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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